Growth Suppressing Activity for Endothelial Cells Induced from Macrophages by Carboxymethylated Curdlan

Abstract

A carboxymethylated derivative of a linear (1→3)-β-D-glucan (CMCD) from Alcaligenes faecalis var. myxogenes acted directly on mouse peritoneal macrophages and mouse lymphoma P388D1 cells, and induced a growth suppressing activity for bovine artery endothelial cells (BAEs) from themselves at a concentration of 100μg/ml. The suppressing activity was also detected in the mouse serum administered as an i.p. injection of CMCD at a dose of 100mg/kg, suggesting that the growth suppressing activity was induced from macrophages potentiated by CMCD in vivo.