Risk assessment report: Food Additives
2,3-Diethylpyrazine
Summary
2014 Volume 2 Issue 4 Pages 176-177
Details
2014 Volume 2 Issue 4 Pages 176-177
The Food Safety Commission of Japan (FSCJ) conducted a risk assessment of 2,3-diethylpyrazine (CAS No.15707–24-1) based on results from various studies. This additive, 2,3-diethylpyrazine, has no apparent toxicity relevant to human health based on the results of studies including the genotoxicity and repeated dose toxicity. The additive (flavoring) was categorized into Structural class II of the report of “Working group on safety assessment method of flavorings” (November 4, 2003) (classification criteria of Structural classes I, II and III are based on Cramer et al. (1978), which are similar to those of Joint FAO/WHO Expert Committee on Food Additives (JECFA)). The safety margin exceeds 1,000 which is regarded as the appropriate safety margin for a 90-day repeated dose toxicity study. The predicted amount of intake (1–2 µg/person/day) is also lower than the acceptable daily intake of Structural class II (540 µg/person/day). FSCJ concluded that 2,3-diethylpyrazine, an additive (flavoring), has no concern relevant to human health when it is used for the purpose of flavoring food.
