Bromvalerylurea and coadministered drugs in serum, gastric fluid and urine were measured by HPLC in 10 cases of acute intoxication. In four cases, bromvalerylurea was collected and in six cases, bromvalerylurea and other drugs were collected.
Morover, 5 microgram/ml of bromvalerylurea in serum was suggested to depress the conscious level of patients. Elimination half-lives were 3.6 hr under treatment of forced diuresis. The bromvalerylurea level in the fatal case was 189.4 microgram/ml in serum.
