経産婦献血者8万人からスクリーニングされた抗血小板同種抗体について

抄録

We detected anti-platelet alloantibodies in the sera from blood donors by MPHA (mixed passive haemagglutination). Anti-Yuk^a antibodies were detected with high frequency (0.12%) and 15 of 21 (71.4%) donors who have anti-Yuk^a antibodies were HLA A24-Bw52-DR2 positive.
The phenotype frequencies of Br^a (HPA-5b) and Br^b (HPA-5a) were estimated to be 8.5% and 99.8% in the Japanese population. The gene frequencies for Br^a (HPA-5b) and Br^b (HPA-5a) were estimated to be 0.043 and 0.959 respectively.