Optically active α,β-disubstituted β-lactone is a useful building blocks. Dyotropic rearrangement is the one of the featured transformation of β-lactone, which involves concurrent migration of two vicinal σ bonds to afford the multifunctionalized γ-butyrolactones. In 2012, two research groups were reported the natural product synthesis using the dyotropic rearrangement of β-lactone to make the 5,7 bicyclic ring systems and a highly constrained bridged spiro-γ-butyrolactone, respectively.