Quinolactacins A, B and C: Novel Quinolone Compounds from Penidllium sp. EPF-6 II. Physico-chemical Properties and Structure Elucidation

SENJI TAKAHASHI; NORIHIRO KAKINUMA; HIROKI IWAI; TADASHI YANAGISAWA; KOJI NAGAI; KENICHI SUZUKI; TATSUHIRO TOKUNAGA; AKIRA NAKAGAWA

doi:10.7164/antibiotics.53.1252

Quinolactacins A, B and C: Novel Quinolone Compounds from Penidllium sp. EPF-6

II. Physico-chemical Properties and Structure Elucidation

SENJI TAKAHASHI, NORIHIRO KAKINUMA, HIROKI IWAI, TADASHI YANAGISAWA, KOJI NAGAI, KENICHI SUZUKI, TATSUHIRO TOKUNAGA, AKIRA NAKAGAWA

Author information

SENJI TAKAHASHI
Department of Biosciences, Teikyo University
NORIHIRO KAKINUMA
United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology
HIROKI IWAI
Department of Biosciences, Teikyo University
TADASHI YANAGISAWA
United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology
KOJI NAGAI
Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
KENICHI SUZUKI
Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
TATSUHIRO TOKUNAGA
Analysis & Metabolism Laboratories, Institute for Drug Discovery Research Yamanouchi Pharmaceutical Co., Ltd.
AKIRA NAKAGAWA
Department of Biosciences, Teikyo University

JOURNAL FREE ACCESS

2000 Volume 53 Issue 11 Pages 1252-1256

DOI https://doi.org/10.7164/antibiotics.53.1252

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Abstract

Three novel quinolone compounds, quinolactacins A (1), B (2) and C (3), Have been found from the fermentation broth of Penidllium sp. EPF-6, a fungus isolated from the larvae of mulberry pyralid (Margaronia pyloalis Welker). The molecular formulas of 1, 2 and 3 were determined to be C₁₆H₁₈N₂O₂, C₁₅H₁₆N₂O₂ and C₁₆H₁₈N₂O₃, respectively by FAB-MS and NMR spectral analyses. The structures of these compounds have a novel quinolone skeleton with a γ-lactam ring consisting of C₁₂H₈N₂O₂ as the common chromophore.

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