New Triene-ansamycins, Thiazinotrienomycins F and G and a Diene-ansamycin, Benzoxazomycin

NOBUO HOSOKAWA; HIROSHI NAGANAWA; MASA HAMADA; HIRONOBU IINUMA; TOMIO TAKEUCHI; KAYOKO S. TSUCHIYA; MAKOTO HORI

doi:10.7164/antibiotics.53.886

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

New Triene-ansamycins, Thiazinotrienomycins F and G and a Diene-ansamycin, Benzoxazomycin

NOBUO HOSOKAWA, HIROSHI NAGANAWA, MASA HAMADA, HIRONOBU IINUMA, TOMIO TAKEUCHI, KAYOKO S. TSUCHIYA, MAKOTO HORI

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JOURNAL FREE ACCESS

2000 Volume 53 Issue 9 Pages 886-894

DOI https://doi.org/10.7164/antibiotics.53.886

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Abstract

New triene-ansamycins designated thiazinotrienomycins F (TT-F) and G (TT-G) and a new diene-ansamycin, benzoxazomycin, were isolated from a culture broth of Streptomyces sp. MJ672-m3 and their structures were elucidated by spectroscopic analyses. The Mean Graphs of TT-G suggests that the tumor growth inhibitory activities are almost as strong as TT-B, in respect of GI₅₀ and TGI against several human cancer cell lines.

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