N-isopropyl-p- 123I Iodoamphetamine Single Photon Emission Computed Tomography Study of Parkinson’s Disease with Dementia

Hideaki MATSUI; Fukashi UDAKA; Takafumi MIYOSHI; Narihiro HARA; Akiko TAMURA; Masaya ODA; Tamotsu KUBORI; Kazuto NISHINAKA; Masakuni KAMEYAMA

doi:10.2169/internalmedicine.44.1046

ORIGINAL ARTICLES

N-isopropyl-p- ¹²³I Iodoamphetamine Single Photon Emission Computed Tomography Study of Parkinson’s Disease with Dementia

Hideaki MATSUI, Fukashi UDAKA, Takafumi MIYOSHI, Narihiro HARA, Akiko TAMURA, Masaya ODA, Tamotsu KUBORI, Kazuto NISHINAKA, Masakuni KAMEYAMA

Author information

Hideaki MATSUI
Department of Neurology, Sumitomo Hospital, Osaka
Fukashi UDAKA
Department of Neurology, Sumitomo Hospital, Osaka
Takafumi MIYOSHI
Department of Psychosomatic Medicine, Sumitomo Hospital, Osaka
Narihiro HARA
Department of Radiology, Sumitomo Hospital, Osaka
Akiko TAMURA
Department of Neurology, Sumitomo Hospital, Osaka
Masaya ODA
Department of Neurology, Sumitomo Hospital, Osaka
Tamotsu KUBORI
Department of Neurology, Sumitomo Hospital, Osaka
Kazuto NISHINAKA
Department of Neurology, Sumitomo Hospital, Osaka
Masakuni KAMEYAMA
Department of Neurology, Sumitomo Hospital, Osaka

Keywords: Parkinson’s disease, dementia, single photon emission computed tomography (SPECT), occipital cortex

JOURNAL OPEN ACCESS

2005 Volume 44 Issue 10 Pages 1046-1050

DOI https://doi.org/10.2169/internalmedicine.44.1046

Details

Abstract

Background Intellectual deterioration occurs in 10-40% of patients with Parkinson’s disease. However, there are many conflicting studies on its relation with brain perfusion and the nature of this dementing process remains controversial.
Objective To compare cortical perfusion by SPECT using ¹²³I-IMP between Parkinson’s disease patients with dementia and those without dementia and to investigate the correlation between dementia in Parkinson’s disease and brain perfusion in various areas.
Methods Fifty-two cases of Parkinson’s disease and 10 control cases were studied. The Parkinson’s disease with dementia group included 30 cases and the Parkinson’s disease without dementia group included 22 cases.
,Results By multiple logistic regression method, we demonstrated significant hypoperfusion in the occipital cortex in Parkinson’s disease with dementia.
Conclusions The cause of dementia in Parkinson’s disease may vary. We demonstrated that occipital hypoperfusion was closely correlated to dementia in Parkinson’s disease compared to frontal, parietal and temporal perfusion.

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