Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Acute Hepatitis due to Hepatitis E Virus Genotype 1 As an Imported Infectious Disease in Japan
Koji Miyahara, Yasuhiro Miyake, Tetsuya Yasunaka, Fusao Ikeda, Akinobu Takaki, Yoshiaki Iwasaki, Haruhiko Kobashi, Jong-Hon Kang, Kazuaki Takahashi, Masahiro Arai, Kazuhide Yamamoto
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Keywords: hepatitis E virus, genotype, acute hepatitis
JOURNAL OPEN ACCESS

2010 Volume 49 Issue 23 Pages 2613-2616

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Abstract

An 18-year-old Nepalese man was admitted due to general malaise and anorexia a month after coming to Japan. Laboratory tests showed elevation of transaminase and positivity for IgM anti-HEV antibody. Serum HEV RNA was detected by RT-PCR amplifications. An HEV genome phylogenetic tree, constructed using an 821-nucleotide sequence in the open reading frame 1, indicated that the genotype was 1. HEV genotype 1 is epidemic in South Asia, Africa and South America, and the incidence of acute hepatitis due to HEV genotype 1 is low in Japan. Thereafter, attention should be paid to HEV genotype 1 infection as an imported infectious disease.

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© 2010 by The Japanese Society of Internal Medicine
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