Primary Aldosteronism with Concurrent Primary Hyperparathyroidism in a Patient with Arrhythmic Disorders

Luigi Petramala; Claudio Savoriti; Laura Zinnamosca; Cristiano Marinelli; Amina Settevendemmie; Camilla Calvieri; Marco Catani; Claudio Letizia

doi:10.2169/internalmedicine.52.8794

CASE REPORTS

Primary Aldosteronism with Concurrent Primary Hyperparathyroidism in a Patient with Arrhythmic Disorders

Luigi Petramala, Claudio Savoriti, Laura Zinnamosca, Cristiano Marinelli, Amina Settevendemmie, Camilla Calvieri, Marco Catani, Claudio Letizia

Author information

Luigi Petramala
Secondary Arterial Hypertension Unit, Department of Internal Medicine and Medical Specialties, "Sapienza" University of Rome, Italy
Claudio Savoriti
Secondary Arterial Hypertension Unit, Department of Internal Medicine and Medical Specialties, "Sapienza" University of Rome, Italy
Laura Zinnamosca
Secondary Arterial Hypertension Unit, Department of Internal Medicine and Medical Specialties, "Sapienza" University of Rome, Italy
Cristiano Marinelli
Secondary Arterial Hypertension Unit, Department of Internal Medicine and Medical Specialties, "Sapienza" University of Rome, Italy
Amina Settevendemmie
Secondary Arterial Hypertension Unit, Department of Internal Medicine and Medical Specialties, "Sapienza" University of Rome, Italy
Camilla Calvieri
Secondary Arterial Hypertension Unit, Department of Internal Medicine and Medical Specialties, "Sapienza" University of Rome, Italy
Marco Catani
Emergency Department, "Sapienza" University of Rome, Italy
Claudio Letizia
Secondary Arterial Hypertension Unit, Department of Internal Medicine and Medical Specialties, "Sapienza" University of Rome, Italy

Keywords: hyperaldosteronism, hyperparathyroidism, arrhythmic disorders, electrolyte disorders

JOURNAL OPEN ACCESS

2013 Volume 52 Issue 18 Pages 2071-2075

DOI https://doi.org/10.2169/internalmedicine.52.8794

Details

Abstract

A 25-year-old Caucasian woman was admitted to our department with severe hypokalemia that was associated with hypercalcemia. An endocrinological investigation showed the coexistence of primary hyperparathyroidism (PHPT) and primary aldosteronism (PA), arising from an adenoma of the left cortical adrenal gland. The patient underwent left laparoscopic adrenalectomy, but refused the surgical neck exploration that would be required for parathyroidectomy. The post-operative course was uneventful, and the patient realized a normalization of her potassium serum level and a reduction of her blood pressure values. We herein report the important issues regarding the management of a severe electrolyte imbalance, in view of the reciprocal interaction between aldosterone and parathyroid hormone, and their combined potential for causing cardiovascular damage.

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