Hereditary Serum Cholinesterase Deficiency Associated with Severe Lipid Deposition in the Kidney

Kazuho HONDA; Wako YUMURA; Junko ARAI; Tsutomu SANAKA; Hiroshi NIHEI; Nobuhiro SUGINO

doi:10.2169/internalmedicine.32.145

Kazuho HONDA, Wako YUMURA, Junko ARAI, Tsutomu SANAKA, Hiroshi NIHEI, Nobuhiro SUGINO

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Keywords: butyryl cholinesterase (pseudocholinesterase), hyperlipidemia, nephrotic syndrome, low density lipoprotein (LDL), LDL apheresis

JOURNAL FREE ACCESS

1993 Volume 32 Issue 2 Pages 145-151

DOI https://doi.org/10.2169/internalmedicine.32.145

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Abstract

A 47-year-old woman who was homozygous for a silent cholinesterase gene (hereditary serum cholinesterase deficiency) presented with nephrotic syndrome and hyperlipidemia. Renal biopsy performed in 1986 demonstrated mesangial proliferative glomerulonephritis. Four years later, a second biopsy revealed progression with mesangial interpositions and severe lipid deposition in the glomeruli, tubules and interstitium. This is the first case of hereditary serum cholinesterase deficiency accompanied by renal disease. Serum cholinesterase deficiency may be related to hyperlipidemia and abnormal lipid deposition in the kidney, which promotes the progression of renal disease.
(Internal Medicine 32: 145- 151 1993)

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