Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Successful Treatment of a Case of Relapsed Acute Promyelocytic Leukemia with Arsenic Trioxide
Yasuo HIRAYAMA, Ryuzo KOYAMA, Tadanori NAGAI, Hidetoshi OHTA, Atsushi KONDO, Kunitsugu ISHIKAWA, Kunihiko ISHITANI, Takuya MATSUNAGA, Sumio SAKAMAKI, Yoshiro NIITSU
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Keywords: ATRA, skin erythema, neuralgia
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2001 Volume 40 Issue 11 Pages 1136-1139

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Abstract

We report a patient with an initial relapse of acute promyelocytic leukemia (APL) who achieved a second complete remission (CR) after treatment with arsenic trioxide. The patient, a 66-year-old woman diagnosed as having relapsed APL, received arsenic trioxide intravenously at a dose of 10 mg/day. At day 36, the patient achieved a second CR. The side effects were slight neuralgia and mild skin erythematous changes, which improved following cessation of the drug. Although arsenic trioxide may be effective for relapsed APL, it should be used with caution because of various complications.
(Internal Medicine 40:1136-1139, 2001)

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