NIPPON SUISAN GAKKAISHI
Online ISSN : 1349-998X
Print ISSN : 0021-5392
ISSN-L : 0021-5392
Antitumor Activity and Immunomodulatory Effect of Glycoprotein Fraction from Scallop Patinopecten yessoensis
Takuma Sasaki, Hiroyuki Uchida, Noriko A. Uchida, Nobuo Takasuka, Yakudo Tachibana, Kazuya Nakamichi, Yoshio Endo, Hisao Kamiya
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1987 Volume 53 Issue 2 Pages 267-272

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Abstract

The liquid from heat treatment of the well-known scallop Patinopecten yessoensis which would normally be discarded as waste has been found to contain a new glycoprotein antineoplastic agent. The fraction composed of 16.8% carbohydrate, 64.5% protein, 2.7% lipid, and 1% nucleic acid exhibited strong antitumor activity. We studied the effects of this fraction on the in vivo growth of tumors. It inhibited tumor growth when injected locally or systematically. Inhibition was not due to direct toxic effects but probably to stimulation of host-mediated responses.

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  • Nippon Suisan Gakkaishi is an official journal of the Japanese Society of Fisheries Science written in Japanese only.
    The society publishes an English journal, Fisheries Science, as well, which accepts submissions from non-members of the society over the world. Detailed information is available in http://jsfs.jp/en/journals/fisheries-science.
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