Spontaneous Pancreatic Islet Amyloidosis in a Greater White-nosed Guenon (Ceropithecus nictitans)

Hyo-Jung Kwon; Mi-Sun Park; Nam-Sik Shin; Doo-Youn Cho; Dae-Yong Kim; Yang-Kyu Choi

doi:10.1293/tox.18.61

Case Report

Spontaneous Pancreatic Islet Amyloidosis in a Greater White-nosed Guenon (Ceropithecus nictitans)

Hyo-Jung Kwon, Mi-Sun Park, Nam-Sik Shin, Doo-Youn Cho, Dae-Yong Kim, Yang-Kyu Choi

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Keywords: amyloidosis, pancreas, monkey

JOURNAL FREE ACCESS

2005 Volume 18 Issue 1 Pages 61-63

DOI https://doi.org/10.1293/tox.18.61

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Abstract

Pancreatic islet amyloidosis from a 15-year-old female greater white-nosed guenon is described. The monkey had been kept in an indoor exhibition facility at the Seoul Grand Park, Korea, and died 2 days after development of anorexia and lethargy. Histologically, amorphic homogeneous eosinophilic, hyalinized material was found deposited in the pancreatic islets and was positive for Congo red stain. The deposits were positive to amyloid A protein and P component by immunohistochemistry. Additionally, glucosuria and ketonuria were detected.

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