2020 年 25 巻 1 号 p. 13-18
Toxicity tests of pharmaceuticals in the eyes are mainly performed in vivo using rabbit eye testing (Draize testing), as indicated in Organization for Economic Cooperation and Development Test Guideline 405. However, in the spirit of protecting animal rights, it is preferable to utilize alternatives to animal testing when performing eye irritant safety tests. Comparison of safety data that had been previously validated through Draize tests with Hansen solubility parameter (HSP) values for test substances made it possible to obtain the potential HSP for the rabbit eyes. Comparison of these rabbit eye HSP values with Modified Maximum Average Scores (MMASs) calculated based on the Ra values that correspond to the distance between the HSP scores for the test substances and the Draize test results indicated that there was a high correlation between the two (r = 0.904, p = 6.10×10−13). These results suggest that if the HSP scores for new substances can be identified, then a comparison to the potential parameters for eyes that have been identified in this study may facilitate highly accurate predictions of eye irritation.
