抄録
We report a case of undifferentiated carcinoma of the extrahepatic bile duct. An 81-year-old woman was admitted with appetite loss and high fever. She was diagnosed with obstructive jaundice due to extrahepatic bile duct carcinoma with bulky lymph node metastases. High fever had continued after the effective percutaneous transhepatic biliary drainage (PTBD) and antibiotics administration. We performed a pancreaticoduodenectomy, and the patient became antipyretic immediately after the surgery. The histological findings revealed undifferentiated carcinoma with multiple lymph node metastases and infiltration of a large number of inflammatory cells in the stroma without abscess or necrosis. Two months after the surgery, high fever appeared together with intrahepatic bile duct recurrence, multiple lymph node metastases, and peritoneal metastases. The patient died 112 days after the surgery. Undifferentiated carcinoma arising from the extrahepatic bile duct is rare, and neoplastic fever was strongly suspected from the clinical course and the findings of examinations in this case.
