Annals of Cancer Research and Therapy
Online ISSN : 1880-5469
Print ISSN : 1344-6835
ISSN-L : 1344-6835
Exploring the Role of Stem Cells in Cancer Development and Progression
Ammar EbrahimiPejman AbbasiMagali Cucchiarini
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2020 Volume 28 Issue 1 Pages 3-8


Tumors comprise two types of non-cancerous cells, first recruited cells such as stem cells and macrophages, and second, tissue-steady cells that are part of the tissue including adipose cells, fibroblasts, and steady macrophage-derived cells, all having a significant impact on tumor progression. This review addresses some effects of stem cells on cancer advancement as the predominant outcome of stem cell therapy on cancer cell lines revealed controversial results. In addition, this review will address some reasons of distinct cancer responses and hypotheses the notion of unfolded protein response as a key switch in cancer development.

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© 2020 by The Japanese Society of Strategies for Cancer Research and Therapy
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