抄録
5'-deoxy-5-fluorouridine (5'-DFUR) has a potent antitumor activity and a negligible effect on the host immune system. No previous studies have been performed on combination therapy with 5'-DFUR and biological response modifiers. In the present study, we evaluated immunochemotherapy with 5'-DFUR and a streptococcal preparation (OK-432). AH66 ascites hepatoma cells were subcutaneously injected into the backs of Donryu rats. 5'-DFUR was administered orally and OK-432 was injected intramuscularly. The tumor size, survival rate, and immune function (lymphocyte subsets in the peripheral blood and chemotactic activity of peritoneal macrophages) were examined.
The results were as follows: (1) The antitumor effect and survival rate were significantly (P<0.05) better in the combination therapy group than in the 5'-DFUR group or the control group. (2) The percentage of helper T cells in the combination therapy group was significantly (P<0.05) higher than in the 5'-DFUR group. (3) The decrease of macrophage chemotactic activity in the combination therapy group and the 5'-DFUR group was negligible compared with that in the control group. These findings suggested that immunochemotherapy with 5'-DFUR and OK-432 deserved clinical assessment.
