抄録
From January to July 1995, 39 patients with non-small cell lung cancer (NSCLC), including 21 with primary squamous cell carcinoma (sq) and 18 with primary adenocarcinoma (ad), were studied to determine changes of T cell subsets using fluorescent monoclonal antibodies (CD3, CD19, CD4, CD8, HLA-DR) and flowcytometry. There were differences between the T cell subsets in preoperative and postoperative patients. Postoperative sq patients showed a significant increase in the percentage of CD4+CD8- cells and the CD4+/CD8+ ratio. Postoperative ad patients showed a significant decrease in the percentage of CD3+CD19- cells and CD3+HLA-DR- cells. We also characterized the changes of T cell subsets in sq and ad patients from each clinical stage. Our results may provide information on the biological behavior of NSCLC and these parameters may be useful for assessing the efficacy of surgical treatment.
