Design of Tissue Adhesive Materials for Biomedical Applications

Abstract

Wound closure using sutures, staplers, and clips are the main medical procedures used after surgical operations. Bioadhesive materials have been additionally used to stop breeding and air leakage at closed wound, however, existing bioadhesive materials have a problem in achieving both strength and biocompatibility. Therefore, we used hydrophobically-modified Alaska pollock gelatin, which is obtained by introducing various hydrophobic groups into gelatin derived from Alaska pollack, which has low-temperature fluidity. The adhesive had excellent burst strength against blood vessels and lung tissue. In addition, it was found that the cured adhesive on the tissue after exhibits an anti-adhesion effect. Also, resulting adhesive materials degraded in rat subcutaneous tissue and showed high biocompatibility. While, tissue-adhesive particles designed for application to early gastrointestinal cancer-removed sites showed excellent coating and perforation closing effects on duodenal tissue. Moreover, the tissue adhesive sheets prepared by the electrospinning method can effectively close the lung tissue just only by pasting. Since these bioadhesive materials are enzymatically degraded in the body without causing a strong inflammatory response, they are expected to be useful as medical materials for tissue adhesion and closure after surgical operations and medical procedures.