Pharmacological Studies of the Isolated Hindgut Movement of Americal Cockroach, Periplaneta americana L. : (Blattaria : Blattidae) : II Effect of Insecticides

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Effect of following insecticides on the isolated cockroach hindgut movement was investigated. They were organophosphorus compounds, carbamates, chlorinated hydrocarbons, nicotine, pyrethrins and several respiratory metabolic inhibitors. Nerve poison insecticides produced stimulatory action, and this stimulatory action may be mostrly related with cholinergic system on the hindgut. Lindane and some other chlorinated hydrocarbon insecticides, also classified as nerve poisons, showed weak stimulatory action and obvious gradual inhibition of the movement. Respirtory metabolic inhibitor insecticides produced gradual inhibition of the movement. High concentrations of insecticides blocked the movement, and recovery of the movement was obtained by repeated washing with new saline. Degree and velocity of the movement recovery depended upon the inhibitory nature of insecticides.