Control of Breathing during Exercise

Abstract

Although the control of breathing during exercise has been studied extensively that both neural and humoral factors may play a role in mediating the exercise hyperpnea, it remalns unresolved whether the response is due solely to neural or humoral mechanisms and how the pulmonary gas exchange matches to the tissue exchange rates. At just onset of exercise ventilation can increase abruptly within I to 2 breathes (Phase I). Such a rapid increment of ventilation is not attributed to the humoral factor(s) due to the circulation delay from muscle metabolites.