2025 Volume 17 Issue 4 Pages 233-238
Alveolar ridge augmentation can generalize difficult prosthetic treatment and improve the predictability of treatment. However, in order to realize safe and reliable regeneration of the alveolar ridge, detailed protocols must be drawn up in accordance with various laws and based on accurate evidence, and manufacturing methods for transplantation agents must be established. The fact that many regenerative medicines using blood concentrates are provided in the field of dentistry in Japan indicates that there is a high need for regenerative medicine. The authors have previously identified the causes of the low adipogenic differentiation potential of mesenchymal stem cells derived from jawbone marrow and various predictive markers of bone formation in vivo for transplanted cells. The authors have developed a novel bone regenerative agent that combines specialized cell sheets with scaffolds, with the aim of applying it to clinical practice.
