Abstract
In the recent reports, apoptosis participate in nervous system during oogenesis and occurrence of degenerative diseases, therefore we investigated about doxorubicin dependent apoptosis in neuronal PC12 cells (pheochromocytoma clone). A toxic model of neuronal degeneration can be produced by doxorubicin, which impairs DNA-dependent RNA synthesis and produces subacute neuronal death. Anti-cancer antibiotics bleomycin, alkyl agent cyclophosphamide, topoisomerase inhibitor etoposide, and metabolic competitor 5-fluorouracil induce apoptosis in some cancer cell lines. We proved that doxorubicin induced apoptosis in neuronal PC12 cells.
