Acute Allergic Reaction due to Milk Proteins Contaminating Lactose Added to Corticosteroid for Injection

Asuka Eda; Kazuko Sugai; Hiromi Shioya; Asako Fujitsuka; Setsuko Ito; Tsutomu Iwata; Tetsunori Funabiki

doi:10.2332/allergolint.C-07-59

CASE REPORT

Acute Allergic Reaction due to Milk Proteins Contaminating Lactose Added to Corticosteroid for Injection

Asuka Eda, Kazuko Sugai, Hiromi Shioya, Asako Fujitsuka, Setsuko Ito, Tsutomu Iwata, Tetsunori Funabiki

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Keywords: allergic reaction, cow's milk allergy, lactose, methylprednisolone sodium succinate, β-lactoglobulin

JOURNAL FREE ACCESS

2009 Volume 58 Issue 1 Pages 137-139

DOI https://doi.org/10.2332/allergolint.C-07-59

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Abstract

We encountered two patients with severe cow's milk allergy who reacted strongly to an injection of methylprednisolone sodium succinate (Sol-Medrol 40mg^® Pfizer, Japan). They came to our hospital because of an asthmatic attack or urticaria and were treated with Sol-Medrol 40mg^®. After the injection, the allergic reaction was immediate. Skin prick tests demonstrated that the β-lactoglobulin contaminating the lactose of the drug preparation caused the immediate allergic reaction.

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