Allergology International
Online ISSN : 1440-1592
Print ISSN : 1323-8930
ISSN-L : 1323-8930
REVIEW ARTICLE
Alarming Dendritic Cells for Allergic Sensitization
Monique AM WillartHamida Hammad
Author information
JOURNAL FREE ACCESS

2010 Volume 59 Issue 2 Pages 95-103

Details
Abstract

Allergic patients mount a Th2 response to common allergens, like house dust mite (HDM), pollens, molds and animal dander. Most inhaled antigens are immunologically inert, however if these antigens are accompanied by microbial or endogenous danger patterns (alarmins), they can be recognized by inflammatory cells. Dendritic cells are the most potent antigen presenting cells, which express a wide variety of receptors on their cell surface, recognizing these microbial patterns, damage induced molecules and cytokines. Dendritic cells become reporters of the microenvironment if exposed to the allergen, subsequently migrating to the draining lymph nodes where they activate naïve T lymphocytes. Dendritic cells could also be indirectly activated by epithelial cells, which express various receptors and secrete a variety of cytokines early after allergen exposure. Upon HDM exposure these cells secrete chemokines to attract monocytes and immature dendritic cells, and GM-CSF, TSLP and IL-33 to activate dendritic cells, mast cells and basophils. Danger signals which alert dendritic cells and epithelial cells comprise many proteins and molecules, contributing to an enhanced immune response to inhaled allergens. This review focuses on the role of dendritic cells and alarmins in the sensitization to inhaled allergens in allergic asthma.

Content from these authors

This article cannot obtain the latest cited-by information.

© 2010 by Japanese Society of Allergology
Next article
feedback
Top