Abstract
Gastrointestinal stromal tumors (GISTs) in the liver are exceedingly rare. We report a case of hepatic GIST with myxoid
changes and hemangiopericytoma-like patterns. A 69-year-old woman presented with epigastric discomfort, and underwent
laparotomy for an extruded tumor in the liver. Five years later, recurrent tumor was excised. The primary tumor contained extensive
necrotic and myxoid areas. Spindle and epithelioid cells plus a few giant cells with abundant myxoid matrix surrounded
the necrotic areas. Immunohistochemically, the spindle cells were distinctly positive for KIT as well as vimentin and smooth
muscle actin, leading to a diagnosis of hepatic GIST. The second excised tumor showed increased cellularity and nuclear
atypia of epithelioid cells with hemangiopericytoma-like patterns. Although rare, we should consider GIST as a differential diagnosis
for a hepatic mesenchymal tumor.
