Determination of Benzydamine Hydrochloride in Serum and Urine by Using a Benzydamine Ion-Selective Piezoelectric Sensor

Abstract

An ion-selective piezoelectric sensor (ISP) was developed for the rapid determination of benzydamine hydrochloride in serum and urine. The ISP device was fabricated by coating a PVC membrane containing benzydamine phosphotungstate on one electrode of a thickness-shear mode piezoelectric quartz crystal. The selective adsorption of benzydamine ion across the membrane caused a decrease in the oscillating frequency; also the logarithm of the frequency shift has a linear relation to the logarithm of the concentration of benzydamine over the ranges 2×10^-7 - 8×10^-3 M with a detection limit of 2.0×10^-7 M at pH 7.0. Influencing factors were investigated and optimized. The results for real samples obtained by the proposed method were in agreement with those by the conventional non-aqueous titrimetric method.