Analytical Sciences
Online ISSN : 1348-2246
Print ISSN : 0910-6340
ISSN-L : 0910-6340
Original Papers
Determination of Lomefloxacin, an Antibacterial Drug, in Pharmaceutical Preparations Based on Its Polarographic Catalytic Wave in the Presence of 2-Iodoacetamide
Jun-feng SONGYong SHAOWei GUO
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JOURNALS FREE ACCESS

2001 Volume 17 Issue 10 Pages 1145-1148

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Abstract

In a 0.125 mol/L phosphate (pH 6.6)/2.5 × 10-4 mol/L 2-iodoacetamide solution, lomefloxacin yields a response of a polarographic catalytic current. The second-order derivative peak current of the catalytic wave of lomefloxacin is proportional to its concentration in the range of 1.0 × 10-8 - 1.0 × 10-6 mol/L (r = 0.998). The sensitivity of the catalytic wave is 25-times higher than that of the corresponding reduction wave for 5.0 × 10-7 mol/L lomefloxacin. The proposed method was applied to the determination of lomefloxacin in pharmaceutical preparations. The polarographic reduction wave is ascribed to a one-electron reduction of the C=C bond of lomefloxacin zwitterion accompanied by an acid-base equilibrium. The catalytic wave should be caused by regeneration of the lomefloxacin molecule at electrode surface due to the one-electron reduction product being further oxidized by electroreductive intermediate products of 2-iodoacetamide.

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© 2001 by The Japan Society for Analytical Chemistry
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