Analytical Sciences
Online ISSN : 1348-2246
Print ISSN : 0910-6340
ISSN-L : 0910-6340
Original Papers
Multiwavelength Spectrophotometric Resolution of the Micro-Equilibria of Cetirizine
Kin Y. TAMLuc QUÉRÉ
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2001 Volume 17 Issue 10 Pages 1203-1208

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Abstract

The acid-base properties of the antihistamine (H1 receptor antagonist) cetirizine have been studied by using a previously developed multiwavelength spectrophotometric titration method. A new computational procedure called “Two-Step-Divide-and-Conquer” (TSDC), which applied evolving factor analysis (EFA) and target factor analysis (TFA), has been derived to unravel the micro-equilibria of the triprotic zwitterionic compound from the spectral data. We have demonstrated that a single spectrophotometric titration experiment is sufficient to determine the 12 unknown microconstants and the distribution of microspecies, which are in good agreement with literature values, where available.

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© 2001 by The Japan Society for Analytical Chemistry
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