Analytical Sciences
Online ISSN : 1348-2246
Print ISSN : 0910-6340
ISSN-L : 0910-6340
Notes
Analysis of Reaction Products of Morphine and Codeine with Hydrogen Peroxide by High-Performance Liquid Chromatography/Mass Spectrometry
Seishi TANAKAReiko IIOSatoshi CHINAKANariaki TAKAYAMAKazuichi HAYAKAWA
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2003 Volume 19 Issue 1 Pages 163-165

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Abstract

Changes in the chemical structures of morphine and codeine in the presence of hydrogen peroxide, a major component of hair dye and decolorant treatments, were examined with high-performance liquid chromatography/mass spectrometry (LC/MS). A mixture of morphine and hydrogen peroxide solution, after incubation at 39°C for 24 h, produced two reaction products (hydroxymorphines). When codeine was used in place of morphine, one reaction product (hydroxycodeine) was produced, in which the benzene ring was hydroxylated.

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© 2003 by The Japan Society for Analytical Chemistry
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