Analytical Sciences
Online ISSN : 1348-2246
Print ISSN : 0910-6340
ISSN-L : 0910-6340
Original Papers
Development of a Headspace GC/MS Analysis for Carbonyl Compounds (Aldehydes and Ketones) in Household Products after Derivatization with o-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine
Naeko SUGAYAKatsumi SAKURAITomoo NAKAGAWANobuhiko ONDASukeo ONODERAMasatoshi MORITAMasakatsu TEZUKA
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2004 Volume 20 Issue 5 Pages 865-870

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Abstract

Carbonyl compounds (aldehydes and ketones) are suspected to be among the chemical compounds responsible for Sick Building Syndrome and Multiple Chemical Sensitivities. A headspace gas chromatography/mass spectrometry (GC/MS) analysis for these compounds was developed using derivatization of the compounds into volatile derivatives with o-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBOA). For GC/MS detection, two ionization modes including electron impact ionization (EI) and negative chemical ionization (NCI) were compared. The NCI mode seemed to be better because of its higher selectivity and sensitivity. This headspace GC/MS (NCI mode) was employed as analysis for aldehydes and ketones in materials (fiber products, adhesives, and printed materials). Formaldehyde was detected in the range of N.D. (not detected) to 39 µg/g; acetaldehyde, N.D. to 4.1 µg/g; propionaldehyde, N.D. to 1.0 µg/g; n-butyraldehyde, N.D. to 0.10 µg/g; and acetone, N.D. to 3.1 µg/g in the samples analyzed.

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© 2004 by The Japan Society for Analytical Chemistry
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