Efficient Oxidizing Agents for Determination of 2,10-Disubstituted Phenothiazines

Abstract

2,10-Disubstituted phenothiazines are the best drugs in psychiatry. Several methods for their analysis have been reported in the literature. The official methods are based on non-aqueous titration or spectrophotometry. Various oxidizing agents have been used for the spectrophotometric determination of 2,10-disubstituted phenothiazines, e.g. Ce(SO₄)₂, NH₄VO₃, K₂S₂O₈, KIO₄, KIO₃, KBrO₃, FeCl₃, NaNO₂, H₂O₂, chloramine T, p-benzoquinone, N-bromosuccinimide. Oxidation reactions of phenothiazines were also used for their determination by flow-injection methods.