Analytical Sciences
Online ISSN : 1348-2246
Print ISSN : 0910-6340
ISSN-L : 0910-6340
Original Papers
Ion-Selective Electrodes for Potentiometric Determination of Ranitidine Hydrochloride, Applying Batch and Flow Injection Analysis Techniques
Yousry M. ISSASayed S. BADAWYAli A. MUTAIR
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JOURNAL FREE ACCESS

2005 Volume 21 Issue 12 Pages 1443-1448

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Abstract

New ranitidine hydrochloride (RaCl)-selective electrodes of the conventional polymer membrane type are described. They are based on incorporation of ranitidine-tetraphenylborate (Ra-TPB) ion-pair or ranitidine-phosphotungstate (Ra-PT) ion-associate in a poly(vinyl chloride) (PVC) membrane plasticized with dioctylphthalate (DOP) or dibutylphthalate (DBP). The electrodes are fully characterized in terms of the membrane composition, solution temperature, and pH. The sensors showed fast and stable responses. Nernstian response was found over the concentration range of 2.0 × 10-5 M to 1.0 × 10-2 M and 1.0 × 10-5 M to 1.0 × 10-2 M in the case of Ra-TPB electrode and over the range of 1.03 × 10-5 M to 1.00 × 10-2 M and 1.0 × 10-5 M to 1.0 × 10-2 M in the case of Ra-PT electrode for batch and FIA systems, respectively. The electrodes exhibit good selectivity for RaCl with respect to a large number of common ions, sugars, amino acids, and components other than ranitidine hydrochloride of the investigated mixed drugs. The electrodes have been applied to the potentiometric determination of RaCl in pure solutions and in pharmaceutical preparations under batch and flow injection conditions with a lower detection limit of 1.26 × 10-5 M and 5.62 × 10-6 M at 25 ± 1°C. An average recovery of 100.91% and 100.42% with a relative standard deviation of 0.72% and 0.53% has been achieved.

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© 2005 by The Japan Society for Analytical Chemistry
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