Analytical Sciences
Online ISSN : 1348-2246
Print ISSN : 0910-6340
ISSN-L : 0910-6340
Original Papers
Development and Validation of a Flow-Injection Assay for Dissolution Studies of the Anti-depressant Drug Venlafaxine
Paraskevas D. TZANAVARASAspasia VERDOUKASDemetrius G. THEMELIS
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2005 Volume 21 Issue 12 Pages 1515-1518

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Abstract

The first flow-injection method has been developed, optimized and validated for the determination of venlafaxine, an antidepressant drug. The method is based on a direct measurement of the absorbance of the analyte in an acidic medium, at 274 nm. Flow-injection parameters, such as sample injection volume and flow rate, were studied and optimized. The proposed method was validated in terms of linearity, repeatability, detection limit, accuracy and selectivity. Linearity was obeyed in the range 30 - 150 mg L-1 of venlafaxine, while the detection limit (1.5 mg L-1) and repeatability (sr < 1.0%, n = 12) were satisfactory. The sampling rate was 30 h-1. The results of dissolution studies of venlafaxine tablets obtained by the proposed method were in good agreement with those by high-performance liquid chromatography.

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© 2005 by The Japan Society for Analytical Chemistry
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