Analytical Sciences
Online ISSN : 1348-2246
Print ISSN : 0910-6340
ISSN-L : 0910-6340
Original Papers
Electrochemical Characteristics of Gatifloxacin and Its Interaction with DNA
Ming GUOQing-Sen YU
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JOURNAL FREE ACCESS

2006 Volume 22 Issue 5 Pages 685-689

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Abstract
The electrochemical behavior of gatifloxacin (GTFX) and its interaction with natural calf thymus DNA (ctDNA) is investigated by differential pulse voltammetry (DPV) on a carbon paraffined electrode. According to the suggested electrochemical equation, a binding constant of 1.7058 × 105 (mol L-1)-1 and binding sizes s = 3.09 (base pairs) of GTFX with ctDNA are obtained by nonlinear fit analysis of electrochemical data. The results demonstrate that GTFX has the properties of an intercalative binder.
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© 2006 by The Japan Society for Analytical Chemistry
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