Nanometer-scale Patterned Surfaces for Control of Cell Adhesion

Makiko GOTO; Takehiko TSUKAHARA; Kae SATO; Tomohiro KONNO; Kazuhiko ISHIHARA; Kiichi SATO; Takehiko KITAMORI

doi:10.2116/analsci.23.245

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Nanometer-scale Patterned Surfaces for Control of Cell Adhesion

Makiko GOTO, Takehiko TSUKAHARA, Kae SATO, Tomohiro KONNO, Kazuhiko ISHIHARA, Kiichi SATO, Takehiko KITAMORI

Author information

Makiko GOTO
Department of Applied Chemistry, School of Engineering, The University of Tokyo
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
Takehiko TSUKAHARA
Department of Applied Chemistry, School of Engineering, The University of Tokyo
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
Kae SATO
Department of Applied Chemistry, School of Engineering, The University of Tokyo
Center for NanoBio Integration, The University of Tokyo
Tomohiro KONNO
Center for NanoBio Integration, The University of Tokyo
Department of Materials Engineering, School of Engineering, The University of Tokyo
Kazuhiko ISHIHARA
Center for NanoBio Integration, The University of Tokyo
Department of Materials Engineering, School of Engineering, The University of Tokyo
Kiichi SATO
Department of Applied Biological Chemistry, School of Agriculture and Life Sciences, The University of Tokyo
Takehiko KITAMORI
Department of Applied Chemistry, School of Engineering, The University of Tokyo
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
Department of Materials Engineering, School of Engineering, The University of Tokyo

JOURNAL FREE ACCESS

2007 Volume 23 Issue 3 Pages 245-247

DOI https://doi.org/10.2116/analsci.23.245

Details

Abstract

A novel cell-adhesion surface, controlled by nanometer-scale topography and chemical patterning, was developed using semiconductor fabrication methods and the formation of self-assembled monolayers. The patterned surface had a sharp contrast between the adsorption and non-adsorption of proteins and cells, and the contrast could be maintained for more than 10 days. The patterning method could easily realize a single cell array and control of the cell morphology. The nanometer-scale patterned surface could control cell adhesion and proliferation. Using the patterned surface will contribute to studies about cell-surface interactions.

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