Analytical Sciences
Online ISSN : 1348-2246
Print ISSN : 0910-6340
ISSN-L : 0910-6340
Original Papers
A Cytosine-rich DNA Decorated Gold Nanoparticles Surface Enhanced Raman-Scattering Platform for Sensitive and Selective Detection of Silver Ions
Hai-Ying QIAOMei-Lan HONGXue TIANLi-Jiao HUANGXia CHU
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2013 Volume 29 Issue 10 Pages 991-996

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Abstract

In this work, we developed a label-free, homogeneous surface-enhanced Raman-scattering (SERS) platform for the rapid, simple and sensitive detection of Ag+ by using the unmodified gold nanoparticles (AuNPs). It utilizes the different absorption properties of single-strand DNA (ssDNA) and double-strand DNA (dsDNA) on citrate-coated AuNPs and specific interactions between Ag+ and cytosine–cytosine pairs. In the presence of Ag+, the structure of ssDNA containing rich cytosine will form a duplex, resulting in the salt-induced aggregation of gold nanoparticles; the corresponding SERS signal transduction can be observed due to the plasmonic coupling of metallic nanoparticles. The assay possesses a superior signal-to-background ratio as high as ∼35.8 with a detection limit of 15 nM. This approach is not only rapid and convenient in operation, but also shows excellent selectivity, which makes it possible to detect Ag+ in actual samples.

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© 2013 by The Japan Society for Analytical Chemistry
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