Imaging Mass Spectrometry Reveals a Decrease of Cardiolipin in the Kidney of NASH Model Mice

Takahiro HAYASAKA; Hirotoshi FUDA; Shu-Ping HUI; Hitoshi CHIBA

doi:10.2116/analsci.32.473

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Imaging Mass Spectrometry Reveals a Decrease of Cardiolipin in the Kidney of NASH Model Mice

Takahiro HAYASAKA, Hirotoshi FUDA, Shu-Ping HUI, Hitoshi CHIBA

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Keywords: Imaging, matrix-assisted laser desorption/ionization, non-alcoholic steatohepatitis, kidney, cardiolipin

JOURNAL FREE ACCESS

2016 Volume 32 Issue 4 Pages 473-476

DOI https://doi.org/10.2116/analsci.32.473

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Abstract

Non-alcoholic steatohepatitis (NASH) can be complicated with chronic kidney disease (CKD). In this study, changes in the distribution of biomolecules in the kidney were studied in NASH model mice with the use of imaging mass spectrometry (IMS). The mass spectra and ion images of IMS showed that the signals of cardiolipin (CL) species were decreased in the kidney cortex of the NASH mice. The decrease of CL might therefore suggest the kidney involvement of NASH.

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