An Analytical Method for Determining Residual Lactide in Polylactide by Gas Chromatography

Xinchao BIAN; Zhiming CHEN; Lidong FENG; Bin SUN; Sheng XIANG; Yanlong LIU; Gao LI; Xuesi CHEN

doi:10.2116/analsci.33.235

Notes

An Analytical Method for Determining Residual Lactide in Polylactide by Gas Chromatography

Xinchao BIAN, Zhiming CHEN, Lidong FENG, Bin SUN, Sheng XIANG, Yanlong LIU, Gao LI, Xuesi CHEN

Author information

Xinchao BIAN
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
Zhejiang Hisun Biomaterials Co., Ltd.
Zhiming CHEN
Zhejiang Hisun Biomaterials Co., Ltd.
Lidong FENG
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
Zhejiang Hisun Biomaterials Co., Ltd.
Bin SUN
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
Zhejiang Hisun Biomaterials Co., Ltd.
Sheng XIANG
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
Zhejiang Hisun Biomaterials Co., Ltd.
Yanlong LIU
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
Zhejiang Hisun Biomaterials Co., Ltd.
Gao LI
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
Xuesi CHEN
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

Keywords: Polylactide, residual monomer, response factor, unstable product, numerical analysis method

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Supplementary material

2017 Volume 33 Issue 2 Pages 235-238

DOI https://doi.org/10.2116/analsci.33.235

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Abstract

An analytical method to determine the residual lactide in polylactide (PLA) was proposed using an internal standard method of gas chromatography (GC). PLA samples and diphenyl ether (DPE) as an internal standard were dissolved in dichloromethane, then PLA was precipitated in anhydrous alcohol. The residual lactide and DPE were extracted to alcohol for GC analysis. At room temperature, lactide could react with alcohol and change into ethyl lactoyl lactate (ELL), but the relative response factor of lactide versus DPE could be obtained through a numerical analysis method. Therefore, the residual lactide content could be quantitatively calculated in PLA. The relative standard deviation (RSD) of the measurements is not more than 7.0%, indicating that the method is suitably precise.

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