Trace Determination of Cyanocobalamin (Vitamin B12) by Analyzing Cobalt Using a Portable Total-Reflection X-ray Fluorescence Spectrometer

Shinsuke KUNIMURA; Yoshie TOKUOKA; Umina AONO

doi:10.2116/analsci.18P330

Original Papers

Trace Determination of Cyanocobalamin (Vitamin B₁₂) by Analyzing Cobalt Using a Portable Total-Reflection X-ray Fluorescence Spectrometer

Shinsuke KUNIMURA, Yoshie TOKUOKA, Umina AONO

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Keywords: Cobalt, solid-phase extraction, portable, total reflection X-ray fluorescence, vitamin B₁₂

JOURNAL FREE ACCESS

2018 Volume 34 Issue 12 Pages 1401-1404

DOI https://doi.org/10.2116/analsci.18P330

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Abstract

A method is presented for the detection of a trace amount of cyanocobalamin (vitamin B₁₂) using a combination of solid-phase extraction and the measurement of cobalt in vitamin B₁₂ by a portable total-reflection X-ray fluorescence spectrometer. Using this combination, a detection limit of 1 ng/mL was achieved for vitamin B₁₂.

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