2021 Volume 37 Issue 11 Pages 1553-1557
The moment analysis method for chromatographic behavior in core-shell columns was simplified. Mass-transfer phenomena other than intra-stationary phase diffusion are analyzed while considering that the packing materials are spherical particles. The manner of intra-stationary phase diffusion is analyzed while assuming a hypothetical flat plate. For most core-shell particles commercially available, the geometry of a spherical thin layer can be supposed as a hypothetical flat plate with a relative error of less than ca. 2% because the thickness of the shell layer is sufficiently smaller than the diameter of whole particle. This supposition makes moment analysis easier because the moment equations for flat plates are simpler than those strictly developed for core-shell particles. Some chromatographic data measured using a core-shell column were analyzed by the simple moment analysis method to confirm its usefulness. It was demonstrated that the method is effective for a preliminary study of mass-transfer kinetics in core-shell columns.
