Use of Cerium(IV) Nitrate in the Spectrophotometric Determination of Levodopa and Methyldopa in the Pure Form and Pharmaceutical Preparations

Abstract

An accurate and simple quantitative method for determining levodopa and methyldopa is proposed. Cerium(IV) has been successively used to react with drugs in 2M H₂SO₄†at 80°C. The absorbance of colored products was measured at 510 and 550nm for levodopa and methyldopa, respectively. The method has been extended to the determination of these drugs in dosage forms. The results have been statistically compared with those obtained by the reference method.