A New Relationship on the Partition Equilibrium of Carboxylic Acids between 1-Octanol/Water and Benzene/Water Systems

Abstract

The partition constants of a number of carboxylic acids were determined for the partition systems using 1-octanol and benzene as a solvent, and the dimerization constants of carboxylic acids in the benzene phase were also determined. A linear relationship between the partition constants (log K_{D, HA}) of carboxylic acids and the molar volume of the respective carboxylic acids was found. A new good relationship on the partition equilibrium of carboxylic acids was found between the partition systems using 1-octanol and benzene, that is, a good linear relationship exists between the values of (log K_{2, HA}+2log K_{D, HA}) for benzene/water system and the values of log K_{D, HA} for 1-octanol/water system, irrespective of the kinds of carboxylic acids.