Abstract
A capillary gas chromatographic method, based on trifluoroacetylated polyols, was applied to a study of urinary polyols in normal subjects and in patients with various diseases. Polyol excretion patterns during fasting periods and circadian variations were studied in normal subjects. Twenty-four hour urine sample sets of normal subjects showed almost constant polyol profiles, suggesting the existence of a polyol regulation system in the body. Excretion patterns of 10 polyols were studied in 100 specimens of 24-h urine samples from patients hospitalized with various diseases. Polyol profiles showed patterns characteristic of pathological states of the diseases: such as diabetes mellitus, chronic renal failure, and chronic liver diseases. The possibility of diagnosis of several diseases by urinary polyol profiles is presented.
