Electrospray Mass Spectrometry: Protonated Molecule Intensities versus Hydration Free Energies in Amino Acids

Minoru SAKAIRI; Alfred L. YERGEY; K. W. Michael SIU; J. C. Yvec Le BLANC; Roger GUEVREMONT; Shier S. BERMAN

doi:10.2116/analsci.7.199

Minoru SAKAIRI, Alfred L. YERGEY, K. W. Michael SIU, J. C. Yvec Le BLANC, Roger GUEVREMONT, Shier S. BERMAN

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Keywords: Electrospray mass spectrometry, hydration free energy, amino acid, protonated molecule intensity

JOURNAL FREE ACCESS

1991 Volume 7 Issue 2 Pages 199-202

DOI https://doi.org/10.2116/analsci.7.199

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Abstract

We demonstrate a high correlation between the natural logarithms of the relative intensities of protonated molecules of amino acids by electrospray and their standard hydration free energies (r=0.98). This result means that the solvation free energy is an important physical parameter for interpreting the difference in protonated molecule intensities by electrospray.

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