Analytical Sciences
Online ISSN : 1348-2246
Print ISSN : 0910-6340
ISSN-L : 0910-6340
DETERMINATION OF ETHAMBUTOL IN PLASMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH FLUORESCENCE DETECTION
Masao SuzukiTomoko OnoShoji Takitani
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1991 Volume 7 Issue Supple Pages 949-950

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Abstract

A high-performance liquid chromatographic method for determining ethambutol (EMB) in plasma has been developed. The method involves the clean-up of plasma EMB with an Extrelut-1 column followed by the pre-column fluorescence derivatization of the drug with 9-fluorenylmethylchloroformate. EMB can be determined in the range of 0.18-18nmol/ml, with a relative standard deviation of 1.88-3.39%. The method is applicable to the measurement of EMB concentration in rabbit plasma after single injection of EMB.

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