A Kinetic Method for the Determination of Carbimazole in Pharmaceutical Preparations by Oxidation with Dichromate in Sulfuric Acid

Abstract

A simple spectrophotometric method is introduced for the determination of carbimazole in drug formulation. The method requires the use of 16mg ml^-1 potassium dichromate, 0.5M sulfuric acid and heating at 90°C for 25min. The method is easily applied to the determination of carbimazole in tablet formulations. The accuracy of the method was tested by a statistical comparison with the British Pharmacopeia official method.