Abstract
Alkylation of calix[4]arene-crown-6 by 2-tert-butoxyethyl bromide with sodium hydride as a base led to 25-(2-tert-butoxyethoxy)-27-hydroxycalix[4]arene-crown-6 in the cone conformation. The conformation of the latter monoalkylated calix[4]arene-crown-6 was established by X-ray crystallography. It crystallizes in the triclinic space group P1. This monoalkylated calixarene-crown-6 can be used as a synthon useful for the preparation of bisalkylated mixed calix[4]arene-crown-6 atropisomers.
