Functional Assessment of Coronary Artery Disease by Myocardial Flow Reserve Versus Pressure-wire Based Assessment A Systematic Review

Osamu Manabe; Tadao Aikawa; Masanao Naya; Shiro Miura; Noriko Oyama-Manabe

doi:10.17996/anc.21-00144

Review Articles

Functional Assessment of Coronary Artery Disease by Myocardial Flow Reserve Versus Pressure-wire Based Assessment

A Systematic Review

Osamu Manabe, Tadao Aikawa, Masanao Naya, Shiro Miura, Noriko Oyama-Manabe

Author information

Keywords: Coronary artery disease, Fractional flow reserve, Instantaneous wave-free ratio, Myocardial blood flow, Myocardial flow reserve, Positron emission tomography

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2021 Volume 7 Issue 1 Pages 57-62

DOI https://doi.org/10.17996/anc.21-00144

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Abstract

Positron emission tomography (PET) permits the noninvasive quantification of myocardial blood flow (MBF). Myocardial flow reserve (MFR), calculated by dividing stress MBF by rest MBF is a reliable index for the functional information of coronary artery disease. A pressure-derived physiological index, such as fractional flow reserve (FFR) is also an important measurement. Both MFR and FFR values are used to evaluate coronary physiology; however, but they are not interchangeable because each test has certain discrepancies.
In this systematic review, we provide an overview of coronary physiology with PET compared to pressure-derived physiological indices.

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Funder information

1.Fund name: the Japan Society of the Promotion of Science (JSPS)

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